Month: December 2019

• Longevity (3)

  Continuing on the information that David Sinclair provides in his book, we’ll have a look here at the 3 pathways he mentioned. Sirtuins, AMPK and mTOR and how these are influenced with a ketogenic diet. mTOR According to his book, mTOR should be kept at low activity. Whenever mTOR is stimulated then the repair mechanisms…

  DesignedByNature

  28 December 2019

  Geen categorie

  ampk, david sinclair, ketogenic diet, lifespan, longevity, mtor, SIRT1, sirtuins

• Breathing Exercise

  Improve your oxygen uptake capacity I have written about tissue oxygen throughout various articles (1, 2) so be sure to check them out for a background of why this type of exercise would be beneficial. In short, apart from a ketogenic diet, regular acute exposure to oxygen deprivation will make your body adapt to be…

  DesignedByNature

  23 December 2019

  Geen categorie

  breathing, heart rate, hematocrit, hemoglobin, pH, red blood cells, routine

• Demand or supply

  Conversion of protein to glucose Among the keto crowd we have people who go full carnivore.  Especially in the carnivore community they have posed that the conversion of protein to glucose (gluconeogenesis or GNG) is demand driven so excess amino acids (from the protein eaten) do not convert to glucose if there is no demand…

  DesignedByNature

  22 December 2019

  Geen categorie

  glucagon, gluconeogenesis, GNG, insulin, ketones, kidneys, liver, postprandial

• Ketogenesis and blood glucose

  It is explained everywhere that the creation of ketones (ketogenesis) is done by the liver, converting fat in ketone bodies such as beta-hydroxybutyrate (BHB). Yet when measuring ketones, after being on the ketogenic diet for a longer period, people struggle with this concept when they measure low ketones. People who have been on a ketogenic…

  DesignedByNature

  16 December 2019

  Geen categorie

  beta-hydroxybutyrate, BHB, blood glucose, fat mass, fat metabolism, ketones, time

• Ketones and oxygen

  If you have read my previous work regarding oxygen and carbon dioxide (CO2) you probably would expect, as I did, that on keto your oxygen saturation in the blood would be huncky dory. But it was not as expected to be 98% or 99%. Instead it is hovering around 96%. Yes there is a certain…

  DesignedByNature

  12 December 2019

  Geen categorie

  acetoacetone, acid base balance, BHB, bicarbonate, chronic diseases, dissociation curve, ketones, oxygen, pH, tissue

• Longevity (2)

  Vaccination Oh dear, do we dare to write about being pro- or anti-vaccination? I think I MUST do it. There is no such thing as censorship in science. And if there is one topic that is very heated at the moment that deserves a lot of attention from science then it is vaccination because the…

  DesignedByNature

  6 December 2019

  Geen categorie

  antivax, david sinclair, longevity, safety, vaccination

• Longevity (1)

  I am almost finished with the book “Lifespan: Why we age – and why we don’t have to” from David Sinclair. In this book he explains the result of his research in a very readable way, avoiding much of the scientific language so that it is accessible to everybody. While reading the book, I recognized…

  DesignedByNature

  4 December 2019

  Geen categorie

  beta-hydroxybutyrate, BHB, brain, david sinclair, health, lifespan, longevity, uncoupling

• CO2 and nutrition

  The different fuel types that are available for our body need to be converted into acetyl-Coa to enter into the citric acid cycle and are processed equally. But the processes to turn glucose and fatty acids (and ketones) into acetyl-Coa are different. One of these differences is that glucose produces carbon dioxide (CO2) while doing…

  DesignedByNature

  3 December 2019

  Geen categorie

  breathing, CAD, carbohydrates, CO2, CVD, diabetes, high fat diet, ketogenic diet, O2, oxygenation