Month: September 2021

• The bigger picture on fat-adaptation

  A paradigm shift in understanding I’ve looked into various topics related to metabolism and what a high fat diet changes versus high carb. Topics such as heat production, weight management, ATP production, protein sparing, lactate, BHB, glycogen, starvation, evolution, bone health and collagen cross-links specifically, pyruvate etc.. have come together in a meaningful way. What…

  DesignedByNature

  27 September 2021

  Geen categorie

  advanced glycation end products, ATP, evolution, glucose, health, heat production, maillard reaction

• Bone health on a ketogenic diet

  Pulling the final plug on attacks Attacks? I follow up on all published papers related to ketosis and although the execution may be done correctly and data may be generated correctly.. the circumstances are often specific and the conclusions are stretched beyond the scope of what the data is representing or can represent. All to…

  DesignedByNature

  10 September 2021

  Geen categorie

  advanced glycation end products, bone density, bone health, bone mineral density, bone quality, cross-links, ketogenic diet, osteoblasts, osteoclasts, protein

• The intimate triad glycogen – lactate – beta-hydroxybutyrate

  There is a close relationship between glycogen, lactate and beta-hydroxybutyrate (BHB) that I would like to highlight in this post. Although it looks like a simple relationship, it has important implications. There is more to cover but I’ll focus on the acute phase. The essence A first scenario, no matter the available fuel type (fat,…

  DesignedByNature

  6 September 2021

  Geen categorie

  ATP, beta-hydroxybutyrate, glycogen, lactate, metabolism

• The speed of the TCA in the liver

  In previous writings I have looked at the liver and also ketone production from different angles but now I want to zoom in a bit on the TCA cycle itself. Previous related writings: The liver buffer(s) Cholesterol or ketones Hepatic glucose metabolism Hepatic glycogen and protein protection In order to accumulate sufficient substrate for ketogenesis,…

  DesignedByNature

  6 September 2021

  Geen categorie

  acetyl-coa, ketogenesis, lactate, TCA cycle