Design a site like this with
Get started

LDL as part of the immune system

Not many people know that the LDL particles which are floating around in our body play an active role in our immune system. I know of the gram-negative bacteria being captured because their endotoxin, lipopolysaccharide (LPS) binds to LPS-binding protein (LBP) via HDL particles (a good reason to have high HDL) and then transfers it on to LDL to get cleared via the liver.

I recently bumped against this Twitter tread. It adds to the knowledge above and because it is a good summary, I didn’t want to let it go lost in the volatile world of tweets. So I’ve taken it as it is so that me or anyone else can dive into it in more detail if they want to.

Here we go…

Staphylococcus aureus alpha-toxin is bound, and almost totally inactivated, in vitro by LDL.

LDL can bind to pH6-Ag, a potential adhesive for the bacterial pathogen Yersinia pestis.

Rats injected with mortal bacterial toxins survive if they are injected with human LDL.

LDL can also bind to certain viruses.

In a meta-analysis of 19 cohort studies including almost 70,000 deaths, it was found an inverse association between serum cholesterol and mortality from respiratory and gastrointestinal diseases, most of which are of an infectious origin.

In another study of more than 100 000 individuals followed for 15 years, a strong, inverse association was found between total cholesterol and the risk of being admitted to hospital because of pneumonia or influenza.

A study of 2446 unmarried men with a previous hx of sexually transmitted disease or liver disease followed for 14 years, a risk ratio for HIV infection of 1.66 was shown in the lowest cholesterol quartile compared with the risk in the second quartile.

Very low total cholesterol is seen in Smith-Lemli-Opitz syndrome, due to imperfect function of an enzyme involved in cholesterol synthesis. Many children with this syndrome are stillborn or die and those who survive have frequent and severe infections.

Individuals with familial hypercholesterolemia (FH) have very high LDL-C and t-C due to LDL-receptor deficiency. In one study three carriers of a mutation for FH were identified through screening. Their standardized mortality ratio was lower than normal.

The authors concluded that environmental factors may participate in the causation of coronary heart disease in FH, and that hypercholesterolemia may have conferred a survival advantage when infectious disease was prevalent.

Certain inflammatory conditions are associated with increased LDL-C.

Problems arise when inflammation turns chronic. Increase in small dense LDL and Lipoprotein(a) occurs in inflammatory diseases but not infections (both atherogenic) L(a) is a LDL variant containing a protein called apolipoprotein(a).

Platelet-activating factor (PAF) is a potent phospholipid mediator that was first described by its ability to cause platelet aggregation and dilation of blood vessels. Under normal conditions, plasma and tissue levels of PAF are tightly regulated by its metabolic pathways.

“However, production of PAF and PAF-like molecules can become elevated and/or dysregulated during extended periods of immune activation and chronic inflammation-related disorders”

“If unresolved, the PAF cycle-related inflammatory activation of endothelial cells leads to tight adhesion of leukocytes on the activated endothelium and subsequent migration of these leukocytes and Ox-LDL to the subendothelium.”

Oxidized low-density lipoprotein (Ox-LDL) is involved in atherogenesis.

Inflammation matters. Melatonin likely helps.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Blog at

%d bloggers like this: