Tag: hypoxia

• Cancer.. where to look for clues

  I’ve been interested in cancer for quite a while. Even before I got affected, the complexity and the link with metabolism caught my attention. Despite digging up all the details of how cancer develops and works, I somehow never could find a distinct feature of a cancer cell. I could not find a single feature…

  DesignedByNature

  27 October 2020

  Geen categorie

  atherosclerosis, cancer, ECM, endothelial dysfunction, extracellular matrix, fatty acid synthase, hypothesis, hypoxia, nitric oxide synthase, tumor

• The curious case of macrophages and LDL cholesterol uptake in the pathology of atherosclerosis

  Recently I wrote an article exploring what could be at the root cause of atherosclerosis. After the publication a comment pointed to the macrophage and cholesterol not being discussed. I didn’t do this because the root cause brought me to a point before macrophage and LDL-cholesterol comes into the picture. But it got me thinking……

  DesignedByNature

  18 October 2020

  Geen categorie

  atherosclerosis, differentiation, hypoxia, inflammation, intima, LDL cholesterol, Lean Mass Huper Responders, M1, M2, macrophages, media, oxidized ldl, proliferation, vasa vasorum

• The cause of atherosclerosis is unknown… or is it?

  

  Medical establishment considers a causal role for cholesterol. There has been a great deal of effort put into lowering cholesterol without significant effect on curing and preventing the disease. How come the failure is so big? Is it really THE cause? I’m especially concerned because my LDL level is >300mg/dL It turns out that the…

  DesignedByNature

  11 October 2020

  Geen categorie

  atherosclerosis, bifurcation, HIF-1alpha, hypoxia, LDL, smoking, sugar, tunica intima, vascular smooth muscle cell, VSMC

• Protein and fructose

  What could those 2 possibly have in common?  Both could be causing us to eat more.  The mechanism and the reason for each is very different though. Let’s have a look. Fructose In a recent podcast, Peter Attia introduced professor Rick Johnson who is an expert in fructose metabolism.  He revealed that fructose is the…

  DesignedByNature

  14 January 2020

  Geen categorie

  cancer, fructose, hunger, hypoxia, metabolism, obesity, protein, protein leverage hypothesis, satiety