Bone health on a ketogenic diet

Pulling the final plug on attacks Attacks? I follow up on all published papers related to ketogenesis and although the execution may be done correctly and data may be generated correctly.. the circumstances are often specific and the conclusions are stretched beyond the scope of what the data is representing or can represent. All toContinue reading “Bone health on a ketogenic diet”

The intimate triad glycogen – lactate – beta-hydroxybutyrate

There is a close relationship between glycogen, lactate and beta-hydroxybutyrate (BHB) that I would like to highlight in this post. Although it looks like a simple relationship, it has important implications. There is more to cover but I’ll focus on the acute phase. The essence A first scenario, no matter the available fuel type (fat,Continue reading “The intimate triad glycogen – lactate – beta-hydroxybutyrate”

The speed of the TCA in the liver

In previous writings I have looked at the liver and also ketone production from different angles but now I want to zoom in a bit on the TCA cycle itself. Previous related writings: The liver buffer(s) Cholesterol or ketones Hepatic glucose metabolism Hepatic glycogen and protein protection In order to accumulate sufficient substrate for ketogenesis,Continue reading “The speed of the TCA in the liver”

Metabolism on a ketogenic diet

Let me first clarify that this article is about a true ketogenic diet, meaning you actually produce higher levels of BHB. Why am I saying this? Because I notice quite a number of people who leave out most carbs but they don’t necessarily reach the ketogenic state due to various reasons. I’ve always said andContinue reading “Metabolism on a ketogenic diet”

A ketogenic diet increases the brain glucose uptake mechanism

When looking into acetoacetone uptake by the brain, I bumped against the following article. I don’t have full access but the abstract showed me the following: Similar trends were observed for (18)FDG uptake with a 1.9-2.6 times increase on the KD and F(asting), respectively (P < 0.05). FDG -> radiolabeled glucose such as used to traceContinue reading “A ketogenic diet increases the brain glucose uptake mechanism”

Insight into evolution

Where do we come from and where is it taking us? Lately I’ve been exposed to different, seemingly unrelated pieces of information. However putting them all on the table, a pattern started to emerge. Join me in a philosophical trip making sense out of evolution and what it could possibly have in storage for us.Continue reading “Insight into evolution”

The fat storage system

Perhaps not a very sexy name but why name it something else than what it is? After studying the functioning of our lipoproteins for a good 2 years (and still not finished learning!), it has finally become clear what those lipoprotein are meant for. As complex as it may be, the end goal is reallyContinue reading “The fat storage system”

CETP

Read it carefully as it may help you assess your risk for cardiovascular disease! In my previous article comparing pathological versus physiological high LDL-C levels, one of the marked differences is that HDL-C goes down under the pathological situation versus up on the physiological case. This difference comes down to cholesterol ester transfer protein orContinue reading “CETP”

Pathologic LDL cholesterol

Throughout all my investigations on the ins and outs of cholesterol, energy metabolism, diseases such as T2 diabetes, cancer, Alzheimer’s, ageing etc.. I learned a lot about the environment of which the circulating lipids can be seen as a proxy for it. In the low carb community, as people get leaner there is a tendencyContinue reading “Pathologic LDL cholesterol”

The key to enhance performance on a high-fat diet

There is a professor (Louise Burke) who looked at athlete performance extensively in elite race-walkers. Shamefully the high-fat community has criticized her and attacked her because the results that she came up with showed that when it comes to world class athletes, there is no performance benefit and more likely there is a slight decrease.Continue reading “The key to enhance performance on a high-fat diet”

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