Tag: lactate

• The intimate triad glycogen – lactate – beta-hydroxybutyrate

  There is a close relationship between glycogen, lactate and beta-hydroxybutyrate (BHB) that I would like to highlight in this post. Although it looks like a simple relationship, it has important implications. There is more to cover but I’ll focus on the acute phase. The essence A first scenario, no matter the available fuel type (fat,…

  DesignedByNature

  6 September 2021

  Geen categorie

  ATP, beta-hydroxybutyrate, glycogen, lactate, metabolism

• The speed of the TCA in the liver

  In previous writings I have looked at the liver and also ketone production from different angles but now I want to zoom in a bit on the TCA cycle itself. Previous related writings: The liver buffer(s) Cholesterol or ketones Hepatic glucose metabolism Hepatic glycogen and protein protection In order to accumulate sufficient substrate for ketogenesis,…

  DesignedByNature

  6 September 2021

  Geen categorie

  acetyl-coa, ketogenesis, lactate, TCA cycle

• A ketogenic diet increases the brain glucose uptake mechanism

  When looking into acetoacetone uptake by the brain, I bumped against the following article. I don’t have full access but the abstract showed me the following: Similar trends were observed for (18)FDG uptake with a 1.9-2.6 times increase on the KD and F(asting), respectively (P < 0.05). FDG -> radiolabeled glucose such as used to trace…

  DesignedByNature

  19 May 2021

  Geen categorie

  astrocytes, blood brain barrier, GLUT1, ketogenic diet, lactate

• Low ketone levels so I utilize them better?

  One of the pervasive thoughts in the keto community is that when they measure lower levels of ketones, the longer they are on the ketogenic diet, that this is caused by a better utilization of the ketones in the body. This is an effect noticed over several months or even years. But is this true?…

  DesignedByNature

  23 March 2020

  Geen categorie

  BHB, blood circulation, brain, heart, ketone utilization, lactate, lung, MCT1

• Berberine on low carb

  I’ve recently came across 2 cases of people who reported elevated glucose and insulin on a low carb diet. Naturally that is alarming because if there is one thing that low carb does well for you, it is to keep glucose and insulin low. It started with a person who recently came to the r/ketoscience…

  DesignedByNature

  7 March 2020

  Geen categorie

  berberine, glucagon, gluconeogenesis, glucose, insulin, ketogenic diet, kidneys, lactate