Hepatic Glucose Metabolism

After writing about the liver buffers I wanted to understand a bit more on the regulation of gluconeogenesis and buildup of the resulting glucose as glycogen in the liver. I have also written about protein being a supply-driven process with the mechanism intended to increase liver glycogen storage. In order for that supply-driven mechanism toContinue reading “Hepatic Glucose Metabolism”

Linking the hepatic glycogen buffer with protein protection

As a short recap of my article on the liver buffer, insulin causes the build-up of glycogen in the liver. When I looked into protein and fructose, I touched the topic of protein protection for the first time. With this article I wanted to go a bit deeper into this aspect and do this byContinue reading “Linking the hepatic glycogen buffer with protein protection”

LMHR and the elevated LDL cholesterol

For those who don’t know, LMHR stands for Lean Mass Hyper Responder and refers to the lipid profile of people who achieve high LDL cholesterol, high HDL cholesterol and low triglycerides. Hyper responder refers to the high LDL that is achieved and lean mass because most of these people appear to have low body fat.Continue reading “LMHR and the elevated LDL cholesterol”

The liver buffer(s)

One of the things I noticed in studying metabolism and the overall functioning of the body, is how important the liver is. A lot of what we do and a lot of what we measure is influenced by the liver and its buffers. Understanding these buffers in conjunction with these measurements may help us aContinue reading “The liver buffer(s)”

Berberine on low carb

I’ve recently came across 2 cases of people who reported elevated glucose and insulin on a low carb diet. Naturally that is alarming because if there is one thing that low carb does well for you, it is to keep glucose and insulin low. It started with a person who recently came to the r/ketoscienceContinue reading “Berberine on low carb”

Cholesterol or ketones, can we have both?

I wanted to know the relationship between and what drives production of cholesterol versus ketones. The simple reason being that 3-hydroxy-3-methylglutaryl Coa or HMG-Coa (HMG) is either reduced by HMG-Coa reductase (HMGr) into the pathway towards cholesterol or HMG-Coa lyase (HMGl) sets it on the pathway towards Acetoacetate. So 2 enzymes work on the sameContinue reading “Cholesterol or ketones, can we have both?”

Demand or supply

Conversion of protein to glucose Among the keto crowd we have people who go full carnivore.  Especially in the carnivore community they have posed that the conversion of protein to glucose (gluconeogenesis or GNG) is demand driven so excess amino acids (from the protein eaten) do not convert to glucose if there is no demandContinue reading “Demand or supply”

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