Tag: cholesterol

• Rebuttal of the Lipid Energy Model hypothesis

  On the 20th of May 2022, the Lipid Energy Model (LEM) was published in an attempt to explain the drastic elevation seen in LDL-c amongst lean individuals who are on a high fat diet with low carbohydrates. The purpose of this rebuttal is to open up discussion on some aspects of the hypothesis so that…

  DesignedByNature

  27 May 2022

  Geen categorie

  cholesterol, glucagon, insulin, ketogenic diet, liver

• Xanthelasma

  People may be affected by a fatty deposition in the eyelids. The effect is more easily seen in people who have elevated levels of cholesterol and is therefor sometimes used as a marker of hyperlipidemia. But I’m not interested in hyperlipidemia although I keep it in mind that lipid deposition is part of the pathology.…

  DesignedByNature

  1 December 2021

  Geen categorie

  bacteria, cholesterol, foam cells, gram-negative, gram-positive, histiocytes, hyperlipidemia, vitamin d, xanthelasma

• The fat storage system

  Perhaps not a very sexy name but why name it something else than what it is? After studying the functioning of our lipoproteins for a good 2 years (and still not finished learning!), it has finally become clear what those lipoprotein are meant for. As complex as it may be, the end goal is really…

  DesignedByNature

  14 February 2021

  Geen categorie

  albumin, ApoB100, ApoC, ApoE, atherosclerosis, cholesterol, fat storage, HDL, insulin resistance, LDL, lipid droplet, lipid system, membrane, phospholipids, plaque, SREBP1, triacylglycerol, triglycerides, vldl

• CETP

  Read it carefully as it may help you assess your risk for cardiovascular disease! In my previous article comparing pathological versus physiological high LDL-C levels, one of the marked differences is that HDL-C goes down under the pathological situation versus up on the physiological case. This difference comes down to cholesterol ester transfer protein or…

  DesignedByNature

  1 February 2021

  Geen categorie

  ampk, atherosclerosis, CETP, cholesterol, fat metabolism, fructose, HDL, LDL, liver, triglycerides, vldl

• Fructose, the really bad guy

  I came across a couple of resources and started to appreciate how different fructose is from glucose. In the low carb community, carbohydrates are obviously avoided or at least high amounts of it as they are generally considered bad. I support this approach but when we zoom in on fructose we notice that it is…

  DesignedByNature

  3 May 2020

  Geen categorie

  appetite, cardiovascular disease, cholesterol, chronic kidney failure, cognitive decline, fructose, fruit, glucose, gout, hippocampus, hypertension, insulin resistance, NAFLD, obesity, overfeeding, satiety, sugar, uric acid, visceral fat

• The liver buffer(s)

  

  One of the things I noticed in studying metabolism and the overall functioning of the body, is how important the liver is. A lot of what we do and a lot of what we measure is influenced by the liver and its buffers. Understanding these buffers in conjunction with these measurements may help us a…

  DesignedByNature

  30 March 2020

  Geen categorie

  ApoB, beta-hydroxybutyrate, BHB, buffer, cholesterol, fatty acids, glucagon, gluconeogenesis, glucose, glycogen, glycogenesis, glycogenolysis, GNG, insulin, ketogenesis, liver

• Cholesterol or ketones, can we have both?

  I wanted to know the relationship between and what drives production of cholesterol versus ketones. The simple reason being that 3-hydroxy-3-methylglutaryl Coa or HMG-Coa (HMG) is either reduced by HMG-Coa reductase (HMGr) into the pathway towards cholesterol or HMG-Coa lyase (HMGl) sets it on the pathway towards Acetoacetate. So 2 enzymes work on the same…

  DesignedByNature

  2 March 2020

  Geen categorie

  carnivore, cholesterol, estrogen, glucagon, HMG-Coa, insulin, ketones, LMHR, T3, thyroid