Rebuttal of the Lipid Energy Model hypothesis

On the 20th of May 2022, the Lipid Energy Model (LEM) was published in an attempt to explain the drastic elevation seen in LDL-c amongst lean individuals who are on a high fat diet with low carbohydrates. The purpose of this rebuttal is to open up discussion on some aspects of the hypothesis so thatContinue reading “Rebuttal of the Lipid Energy Model hypothesis”

Xanthelasma

People may be affected by a fatty deposition in the eyelids. The effect is more easily seen in people who have elevated levels of cholesterol and is therefor sometimes used as a marker of hyperlipidemia. But I’m not interested in hyperlipidemia although I keep it in mind that lipid deposition is part of the pathology.Continue reading “Xanthelasma”

The fat storage system

Perhaps not a very sexy name but why name it something else than what it is? After studying the functioning of our lipoproteins for a good 2 years (and still not finished learning!), it has finally become clear what those lipoprotein are meant for. As complex as it may be, the end goal is reallyContinue reading “The fat storage system”

CETP

Read it carefully as it may help you assess your risk for cardiovascular disease! In my previous article comparing pathological versus physiological high LDL-C levels, one of the marked differences is that HDL-C goes down under the pathological situation versus up on the physiological case. This difference comes down to cholesterol ester transfer protein orContinue reading “CETP”

Fructose, the really bad guy

I came across a couple of resources and started to appreciate how different fructose is from glucose. In the low carb community, carbohydrates are obviously avoided or at least high amounts of it as they are generally considered bad. I support this approach but when we zoom in on fructose we notice that it isContinue reading “Fructose, the really bad guy”

The liver buffer(s)

One of the things I noticed in studying metabolism and the overall functioning of the body, is how important the liver is. A lot of what we do and a lot of what we measure is influenced by the liver and its buffers. Understanding these buffers in conjunction with these measurements may help us aContinue reading “The liver buffer(s)”

Cholesterol or ketones, can we have both?

I wanted to know the relationship between and what drives production of cholesterol versus ketones. The simple reason being that 3-hydroxy-3-methylglutaryl Coa or HMG-Coa (HMG) is either reduced by HMG-Coa reductase (HMGr) into the pathway towards cholesterol or HMG-Coa lyase (HMGl) sets it on the pathway towards Acetoacetate. So 2 enzymes work on the sameContinue reading “Cholesterol or ketones, can we have both?”

Create your website with WordPress.com
Get started