Tag: liver

• Rebuttal of the Lipid Energy Model hypothesis

  On the 20th of May 2022, the Lipid Energy Model (LEM) was published in an attempt to explain the drastic elevation seen in LDL-c amongst lean individuals who are on a high fat diet with low carbohydrates. The purpose of this rebuttal is to open up discussion on some aspects of the hypothesis so that…

  DesignedByNature

  27 May 2022

  Geen categorie

  cholesterol, glucagon, insulin, ketogenic diet, liver

• CETP

  Read it carefully as it may help you assess your risk for cardiovascular disease! In my previous article comparing pathological versus physiological high LDL-C levels, one of the marked differences is that HDL-C goes down under the pathological situation versus up on the physiological case. This difference comes down to cholesterol ester transfer protein or…

  DesignedByNature

  1 February 2021

  Geen categorie

  ampk, atherosclerosis, CETP, cholesterol, fat metabolism, fructose, HDL, LDL, liver, triglycerides, vldl

• Why are mice bad at ketogenesis?

  Previously I collected different studies to see how the mice perform on ketogenesis. Despite having a diet that often consists of >90% fat they produce disappointingly low BHB levels. Without thinking much about it I just assumed they are bad at fat metabolism biased by thinking they are typical high carb eating animals so they…

  DesignedByNature

  1 October 2020

  Geen categorie

  carnitine, exercise, fat metabolism, ketogenesis, LCFA, liver, long chain fatty acids, MCFA, medium chain fatty acids, mice

• LMHR and the elevated LDL cholesterol

  For those who don’t know, LMHR stands for Lean Mass Hyper Responder and refers to the lipid profile of people who achieve high LDL cholesterol, high HDL cholesterol and low triglycerides. Hyper responder refers to the high LDL that is achieved and lean mass because most of these people appear to have low body fat.…

  DesignedByNature

  6 April 2020

  Geen categorie

  ApoB100, carnivore, free T3, glucagon, incretins, insulin, ketogenic diet, LDL cholesterol, LDL receptor, liver, LMHR, pulsatile

• The liver buffer(s)

  

  One of the things I noticed in studying metabolism and the overall functioning of the body, is how important the liver is. A lot of what we do and a lot of what we measure is influenced by the liver and its buffers. Understanding these buffers in conjunction with these measurements may help us a…

  DesignedByNature

  30 March 2020

  Geen categorie

  ApoB, beta-hydroxybutyrate, BHB, buffer, cholesterol, fatty acids, glucagon, gluconeogenesis, glucose, glycogen, glycogenesis, glycogenolysis, GNG, insulin, ketogenesis, liver

• Demand or supply

  Conversion of protein to glucose Among the keto crowd we have people who go full carnivore.  Especially in the carnivore community they have posed that the conversion of protein to glucose (gluconeogenesis or GNG) is demand driven so excess amino acids (from the protein eaten) do not convert to glucose if there is no demand…

  DesignedByNature

  22 December 2019

  Geen categorie

  glucagon, gluconeogenesis, GNG, insulin, ketones, kidneys, liver, postprandial