Author: DesignedByNature
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Raising skeletal muscle carnitine
Carnitine is required to bring the longer chain fatty acids into the mitochondrial matrix where it can be further broken down to produce ATP. Carnitine Palmitoil Transferase 1a (CPT1a) is a mitochondrial outer membrane bound protein that will take in an acyl-CoA and bind it to carnitine resulting in acyl-carnitine. On a ketogenic diet (KD),…
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LDL as part of the immune system
Not many people know that the LDL particles which are floating around in our body play an active role in our immune system. I know of the gram-negative bacteria being captured because their endotoxin, lipopolysaccharide (LPS) binds to LPS-binding protein (LBP) via HDL particles (a good reason to have high HDL) and then transfers it…
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Ketones support the failing heart and may help repair it
I noticed that in the past few years there is quite a bit of research coming out investigating the effect of beta-hydroxybutyrate on a failing heart. It seems that a failing heart somehow increases the production of ketones which it then consumes to support its function. As this is picking up attention in the scientific…
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Endurance training
My most favorite sport is cycling and being an enthusiast on understanding energy metabolism, there’s an interesting triangle to form with the field of ketosis and sport performance. I originally started with thinking there’s a performance benefit when combining eating low carb with endurance due to the higher level of fat burning achieved and possible…
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Heat acclimation & ketogenic diet
What does heat acclimation do to ketogenesis or is there any effect of the ketogenic diet on heat acclimation that is different from a more common SAD diet? I recently have been exposed to a hot climate and observed some weight loss (sweating, appetite loss, higher cycling mileage, …) and what felt like a reduction…
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Rebuttal of the Lipid Energy Model hypothesis
On the 20th of May 2022, the Lipid Energy Model (LEM) was published in an attempt to explain the drastic elevation seen in LDL-c amongst lean individuals who are on a high fat diet with low carbohydrates. The purpose of this rebuttal is to open up discussion on some aspects of the hypothesis so that…
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A world dominated by psychopaths
Our gut feeling says this is not the most ideal vision. Yet, with what I am about to unravel, this is exactly the path we are on. This article will be big and lengthy because I want you to grasp the full extent of the reach, the ideas and the consequences. This is about your…
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Cerebral glycogen levels influence endurance capacity
A recent paper was published in which Timothy Noakes PhD reviewed current evidence on what sustains endurance and came to the conclusion it is not based on muscle fatigue but rather on something unknown that does involve the brain. “What Is the Evidence That Dietary Macronutrient Composition Influences Exercise Performance? A Narrative Review” https://www.mdpi.com/2072-6643/14/4/862/htm When…
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Go vegan, save the animals???
From the moment humanity developed agriculture, it allowed populations to expand but it wasn’t until the industrial evolution that our population saw an explosive growth. The extraction of energy was a turning point but it was only possible to sustain that population if humans managed to secure the equally explosive demand for food. Obviously humans…
Designed By Nature 