Metabolism on a ketogenic diet

Let me first clarify that this article is about a true ketogenic diet, meaning you actually produce higher levels of BHB. Why am I saying this? Because I notice quite a number of people who leave out most carbs but they don’t necessarily reach the ketogenic state due to various reasons. I’ve always said andContinue reading “Metabolism on a ketogenic diet”

A ketogenic diet increases the brain glucose uptake mechanism

When looking into acetoacetone uptake by the brain, I bumped against the following article. I don’t have full access but the abstract showed me the following: Similar trends were observed for (18)FDG uptake with a 1.9-2.6 times increase on the KD and F(asting), respectively (P < 0.05). FDG -> radiolabeled glucose such as used to traceContinue reading “A ketogenic diet increases the brain glucose uptake mechanism”

Insight into evolution

Where do we come from and where is it taking us? Lately I’ve been exposed to different, seemingly unrelated pieces of information. However putting them all on the table, a pattern started to emerge. Join me in a philosophical trip making sense out of evolution and what it could possibly have in storage for us.Continue reading “Insight into evolution”

The fat storage system

Perhaps not a very sexy name but why name it something else than what it is? After studying the functioning of our lipoproteins for a good 2 years (and still not finished learning!), it has finally become clear what those lipoprotein are meant for. As complex as it may be, the end goal is reallyContinue reading “The fat storage system”

CETP

Read it carefully as it may help you assess your risk for cardiovascular disease! In my previous article comparing pathological versus physiological high LDL-C levels, one of the marked differences is that HDL-C goes down under the pathological situation versus up on the physiological case. This difference comes down to cholesterol ester transfer protein orContinue reading “CETP”

Pathologic LDL cholesterol

Throughout all my investigations on the ins and outs of cholesterol, energy metabolism, diseases such as T2 diabetes, cancer, Alzheimer’s, ageing etc.. I learned a lot about the environment of which the circulating lipids can be seen as a proxy for it. In the low carb community, as people get leaner there is a tendencyContinue reading “Pathologic LDL cholesterol”

The key to enhance performance on a high-fat diet

There is a professor (Louise Burke) who looked at athlete performance extensively in elite race-walkers. Shamefully the high-fat community has criticized her and attacked her because the results that she came up with showed that when it comes to world class athletes, there is no performance benefit and more likely there is a slight decrease.Continue reading “The key to enhance performance on a high-fat diet”

Cancer.. where to look for clues

I’ve been interested in cancer for quite a while. Even before I got affected, the complexity and the link with metabolism caught my attention. Despite digging up all the details of how cancer develops and works, I somehow never could find a distinct feature of a cancer cell. I could not find a single featureContinue reading “Cancer.. where to look for clues”

The curious case of macrophages and LDL cholesterol uptake in the pathology of atherosclerosis

Recently I wrote an article exploring what could be at the root cause of atherosclerosis. After the publication a comment pointed to the macrophage and cholesterol not being discussed. I didn’t do this because the root cause brought me to a point before macrophage and LDL-cholesterol comes into the picture. But it got me thinking…Continue reading “The curious case of macrophages and LDL cholesterol uptake in the pathology of atherosclerosis”

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