Author: DesignedByNature
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Insulin Resistance
Research in the past and present has shown us that fat causes insulin resistance. With ketogenic diets becoming increasingly popular, many people fear for a potential negative effect by inducing this insulin resistance. It is true that insulin resistance does appear on low carb high fat diets such as the ketogenic diet but the context…
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Low ketone levels so I utilize them better?
One of the pervasive thoughts in the keto community is that when they measure lower levels of ketones, the longer they are on the ketogenic diet, that this is caused by a better utilization of the ketones in the body. This is an effect noticed over several months or even years. But is this true?…
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Immune cell modulation by the ketogenic diet
What follows is a list of research that shows how a ketogenic diet can have effect on the immune system. A lot of this research is done in non-human bodies or circumstances so none of it has been proven to be similar in humans. This is very important to know because mice and rats have…
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Berberine on low carb
I’ve recently came across 2 cases of people who reported elevated glucose and insulin on a low carb diet. Naturally that is alarming because if there is one thing that low carb does well for you, it is to keep glucose and insulin low. It started with a person who recently came to the r/ketoscience…
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Oxidized LDL
When looking at the risk calculators for cardiovascular disease, your risk of coronary atherosclerosis is calculated based on several factors. Today we already see that LDL alone doesn’t create much of a risk when using the industry top ranked tools. It looks like science has moved on while medical care and general public is still…
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Cholesterol or ketones, can we have both?
I wanted to know the relationship between and what drives production of cholesterol versus ketones. The simple reason being that 3-hydroxy-3-methylglutaryl Coa or HMG-Coa (HMG) is either reduced by HMG-Coa reductase (HMGr) into the pathway towards cholesterol or HMG-Coa lyase (HMGl) sets it on the pathway towards Acetoacetate. So 2 enzymes work on the same…
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Rodents on KD
There are quite a number of papers studying ketosis in rodents to measure outcomes. I just thought it would be a neat exercise to make an inventory of these studies and look at their properties such as feeding ad libitum, type of fat in the diet, level of ketosis reached etc.. to see if we…
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Longevity (3)
Continuing on the information that David Sinclair provides in his book, we’ll have a look here at the 3 pathways he mentioned. Sirtuins, AMPK and mTOR and how these are influenced with a ketogenic diet. mTOR According to his book, mTOR should be kept at low activity. Whenever mTOR is stimulated then the repair mechanisms…
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Breathing Exercise
Improve your oxygen uptake capacity I have written about tissue oxygen throughout various articles (1, 2) so be sure to check them out for a background of why this type of exercise would be beneficial. In short, apart from a ketogenic diet, regular acute exposure to oxygen deprivation will make your body adapt to be…
Designed By Nature 