Cholesterol or ketones, can we have both?

I wanted to know the relationship between and what drives production of cholesterol versus ketones. The simple reason being that 3-hydroxy-3-methylglutaryl Coa or HMG-Coa (HMG) is either reduced by HMG-Coa reductase (HMGr) into the pathway towards cholesterol or HMG-Coa lyase (HMGl) sets it on the pathway towards Acetoacetate. So 2 enzymes work on the sameContinue reading “Cholesterol or ketones, can we have both?”

Rodents on KD

There are quite a number of papers studying ketosis in rodents to measure outcomes. I just thought it would be a neat exercise to make an inventory of these studies and look at their properties such as feeding ad libitum, type of fat in the diet, level of ketosis reached etc.. to see if weContinue reading “Rodents on KD”

Protein and fructose

What could those 2 possibly have in common?  Both could be causing us to eat more.  The mechanism and the reason for each is very different though. Let’s have a look. Fructose In a recent podcast, Peter Attia introduced professor Rick Johnson who is an expert in fructose metabolism.  He revealed that fructose is theContinue reading “Protein and fructose”

Longevity (3)

Continuing on the information that David Sinclair provides in his book, we’ll have a look here at the 3 pathways he mentioned. Sirtuins, AMPK and mTOR and how these are influenced with a ketogenic diet. mTOR According to his book, mTOR should be kept at low activity. Whenever mTOR is stimulated then the repair mechanismsContinue reading “Longevity (3)”

Breathing Exercise

Improve your oxygen uptake capacity I have written about tissue oxygen throughout various articles (1, 2) so be sure to check them out for a background of why this type of exercise would be beneficial. In short, apart from a ketogenic diet, regular acute exposure to oxygen deprivation will make your body adapt to beContinue reading “Breathing Exercise”

Demand or supply

Conversion of protein to glucose Among the keto crowd we have people who go full carnivore.  Especially in the carnivore community they have posed that the conversion of protein to glucose (gluconeogenesis or GNG) is demand driven so excess amino acids (from the protein eaten) do not convert to glucose if there is no demandContinue reading “Demand or supply”

Ketogenesis and blood glucose

It is explained everywhere that the creation of ketones (ketogenesis) is done by the liver, converting fat in ketone bodies such as beta-hydroxybutyrate (BHB). Yet when measuring ketones, after being on the ketogenic diet for a longer period, people struggle with this concept when they measure low ketones. People who have been on a ketogenicContinue reading “Ketogenesis and blood glucose”

Ketones and oxygen

If you have read my previous work regarding oxygen and carbon dioxide (CO2) you probably would expect, as I did, that on keto your oxygen saturation in the blood would be huncky dory. But it was not as expected to be 98% or 99%. Instead it is hovering around 96%. Yes there is a certainContinue reading “Ketones and oxygen”

Longevity (1)

I am almost finished with the book “Lifespan: Why we age – and why we don’t have to” from David Sinclair. In this book he explains the result of his research in a very readable way, avoiding much of the scientific language so that it is accessible to everybody. While reading the book, I recognizedContinue reading “Longevity (1)”

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