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Oxidized LDL
When looking at the risk calculators for cardiovascular disease, your risk of coronary atherosclerosis is calculated based on several factors. Today we already see that LDL alone doesn’t create much of a risk when using the industry top ranked tools. It looks like science has moved on while medical care and general public is still…
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Cholesterol or ketones, can we have both?
I wanted to know the relationship between and what drives production of cholesterol versus ketones. The simple reason being that 3-hydroxy-3-methylglutaryl Coa or HMG-Coa (HMG) is either reduced by HMG-Coa reductase (HMGr) into the pathway towards cholesterol or HMG-Coa lyase (HMGl) sets it on the pathway towards Acetoacetate. So 2 enzymes work on the same…
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Rodents on KD
There are quite a number of papers studying ketosis in rodents to measure outcomes. I just thought it would be a neat exercise to make an inventory of these studies and look at their properties such as feeding ad libitum, type of fat in the diet, level of ketosis reached etc.. to see if we…
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Longevity (3)
Continuing on the information that David Sinclair provides in his book, we’ll have a look here at the 3 pathways he mentioned. Sirtuins, AMPK and mTOR and how these are influenced with a ketogenic diet. mTOR According to his book, mTOR should be kept at low activity. Whenever mTOR is stimulated then the repair mechanisms…
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Breathing Exercise
Improve your oxygen uptake capacity I have written about tissue oxygen throughout various articles (1, 2) so be sure to check them out for a background of why this type of exercise would be beneficial. In short, apart from a ketogenic diet, regular acute exposure to oxygen deprivation will make your body adapt to be…
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Demand or supply
Conversion of protein to glucose Among the keto crowd we have people who go full carnivore. Especially in the carnivore community they have posed that the conversion of protein to glucose (gluconeogenesis or GNG) is demand driven so excess amino acids (from the protein eaten) do not convert to glucose if there is no demand…
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Ketones and oxygen
If you have read my previous work regarding oxygen and carbon dioxide (CO2) you probably would expect, as I did, that on keto your oxygen saturation in the blood would be huncky dory. But it was not as expected to be 98% or 99%. Instead it is hovering around 96%. Yes there is a certain…
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Longevity (2)
Vaccination Oh dear, do we dare to write about being pro- or anti-vaccination? I think I MUST do it. There is no such thing as censorship in science. And if there is one topic that is very heated at the moment that deserves a lot of attention from science then it is vaccination because the…
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